Neurosis And Human Growth Epub 17 ##BEST##
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Evidence has implicated the upregulation of VEGF in the pathogenesis of radiation induced brain necrosis making it an attractive therapeutic target (25,26). Bevacizumab, a humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF), is an anti-angiogenic therapy with the best-supported evidence in patients with symptomatic RN who respond poorly to corticosteroids as initial symptomatic management (27-30). Pharmacologic blockage of VEGF with bevacizumab can restore BBB function and markedly reduce cerebral edema and mass effect with subsequent improvement in neurologic symptoms (27). 153554b96e